We found that GALNT5 knockdown treatment alone or FOI treatment alone could promote the decrease of the proportion of G0/G1 phase cells, and this phenomenon was more obvious when the two treatments were given at the same time, mainly because GALNT5 knockdown treatment and FOI treatment caused significant S phase or G2/M phase arrest of pancreatic cancer cells (Fig. 3E-F) In summary, GALNT5 confers FOI resistance on PDAC cells. This evidence concerns the gene GALNT5 and familial pancreatic carcinoma.