The volume and weight analysis of mouse PDX pancreatic cancer model obtained the same results as that of the orthotopic xenograft model (Fig. 6G-J) We further carried out HE and histochemical staining on PDX model samples, and the results showed that: the PDX tissue differentiation in the Vehicle-ShCtrl group was the lowest, the PDX tissue differentiation was improved after FOI treatment alone or GALNT5 knockdown, and the group FOI- ShGALNT5 receiving FOI treatment and GALNT5 knockdown at the same time had the highest degree of differentiation (Fig. 6K). Here, GALNT5 is linked to familial pancreatic carcinoma.