To verify the interaction of the GALNT5-MYH9-NICD axis in vivo, we used the same mouse KPC1199 cell implanted orthotopic xenograft tumor model and the mouse pancreatic cancer PDX model as in the above experiment, and all models were treated with FOI once a week to restore the clinical administration status. The gene discussed is GALNT5; the disease is familial pancreatic carcinoma.