To model the upregulation of Lypd6 and Lypd6b in the brain during neurological diseases, we used a mouse model with intracerebroventricular delivery of recombinant water-soluble domains of Lypd6 and Lypd6b (ws-Lypd6 and ws-Lypd6b) into the brain. This evidence concerns the gene LYPD6 and nervous system disorder.