TF and metastatic neoplasm: Similarly, patients with resectable liver lesions had significantly lower baseline tumor fractions as assessed by DELFI-TF and ddPCR (p < 0.05 for both, Kruskal–Wallis) (Fig. 3b) and DELFI-TF was lower in patients with metachronous compared to synchronous metastatic disease (p < 0.001, Wilcoxon rank-sum) (Fig. 3c).