MDA-MB-231 cells were exposed to PTX before and after NLRP3 knock-down and the results indicated up-regulation of inflammasome components, such as NLRP3 (p < 0.001), ASC (p < 0.0001), NOD2 (p < 0.001) and pyroptosis, such as caspase-1 (p < 0.001), IL-1β (p < 0.05), IL-18 (p < 0.01), GSDMD (p < 0.01) in PTX-treated tumor cells. The gene discussed is GSDMD; the disease is neoplasm.