Consequently, the aim of the current study was to contribute to a better understanding of NLRP3 inflammasome signaling in TNBC pathogenesis and to observe the capacity of PTX to influence NLRP3 inflammasome activation, maturation of caspase-1 and secretion of IL-1β under pharmacological inhibition or genetic silencing of NLRP3 inflammasome, in order to provide a possible effective anti-tumor strategy. This evidence concerns the gene CASP1 and neoplasm.