In summary, the current study demonstrates that LINC01503 may regulate VEGFA expression through the miR-342-3p/VEGFA and HSP60/VEGFA axes, activate the AKT signaling pathway downstream of VEGFA in vascular endothelial cells in a paracrine manner, and promote angiogenesis, which in turn drives CRC progression. Here, VEGFA is linked to colorectal carcinoma.