LINC01503 and colorectal carcinoma: To investigate whether the increased expression of LINC01503 in CRC cell lines was related to abnormal histone modifications, we conducted a genomic bioinformatics analysis using the UCSC Genome Browser (http://genome.ucsc.edu/), and found a significant enrichment of the H3K27ac peak in the promoter region of LINC01503 (Supplementary Fig. 5A, available online), indicating that LINC01503 transcription might be regulated by H3K27ac modification.