In C33A cells, a carcinoma cell line, DSN1, has a mutation at Ser109, which is the Aurora B phosphorylation site that regulates the CENP-C-Mis12C interaction (DepMap: https://depmap.org/portal/), suggesting that the CENP-C-Mis12C–mediated Aurora B regulatory loop may be impaired in some cancer cells. The gene discussed is CENPC; the disease is cancer.