Between 14 and 20 wk after the initial 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) treatment, CenpcΔM12BD/ΔM12BD mice formed significantly more papillomas than Cenpc+/+ or Cenpc+/ΔM12BD mice (Fig 2B and C). This evidence concerns the gene CENPC and papilloma.