Increased EGF and EGFR staining is observed in the retinas of patients with PDR (Patel et al., 1994), and inhibition of the EGFR reduces macula oedema (Sugimoto et al., 2013), angiogenesis, and inflammation (Ju et al., 2019) in mouse models of diabetes and diabetic retinopathy. Here, EGFR is linked to diabetes mellitus.