Interestingly, FGFR2-mediated stimulation of glucose uptake, ECAR, lactate production and HK2 and LDHA expression in patient-derived FGFR2-mutant ICC cells is dependent on the transcription factor NF-κB (Zhen et al., 2024). Here, FGFR2 is linked to intrahepatic cholangiocarcinoma.