In addition to increasing Pfk and glyceraldehyde 3-phosphate dehydrogenase (Gapdh) expression, TNFα promotes glucose consumption and lactate production in mouse fibrosarcoma cells (Sánchez-Alcázar et al., 2003), myoblasts (Remels et al., 2015), and pancreatic cancer cells (M. Liu et al., 2016b). Here, GAPDH is linked to familial pancreatic carcinoma.