Sod1 and Sod2-deficient mice, as well as mice lacking the antioxidant transcription factor, nuclear factor erythroid 2-related factor 2 (NRF2), mimic many pathological features of AMD including drusen-like deposits, declining ERG responses, CNV, and photoreceptor degeneration (Imamura et al., 2006; Mao et al., 2014; Z. Zhao et al., 2011b). The gene discussed is NFE2L2; the disease is age-related macular degeneration.