FGFR2 and intrahepatic cholangiocarcinoma: Moreover, FGFR inhibition in FGFR2-mutant ICC cells results in mitochondrial abnormalities, decreasing the number of fragmented mitochondria while increasing the number of elongated mitochondria, accompanied by decreased glucose carbon labelling of the TCA cycle intermediates citrate, α-KG, and malate (Zhen et al., 2024).