PFKFB3 and colorectal cancer: Treatment with IL-6 promotes expression of the glycolytic genes SLC2A1, HK2, PKM2, PFKFB3, and LDHA in human colorectal cancer cells (Han et al., 2016), and similarly induces Hk2, Pkm2, and Pfkfb3 expression in murine macrophages (Kumari et al., 2020).