STX7 and lysosomal storage disease: Corroborating a previous report in cells derived from a lysosomal storage disorder mouse model (35), we saw increased formation of likely nonfunctional Stx7 supercomplexes upon apilimod treatment in the TX-114 insoluble fraction (Fig. 6G), indicating its sequestration on complex, perhaps cholesterol-rich membrane compartments akin to lipid rafts.