The DNAJB-PRKACA gene fusion, created by the fusion of a subunit of the HSP40 complex (DNAJB) and the catalytic subunit of protein kinase A (PRKACA), creates a fusion kinase and drives fibrolamellar hepatocellular carcinoma, and PTMs of this kinase could impact cancer progression (155). The gene discussed is PRKACA; the disease is cancer.