For instance, hypothalamic Ucn3-expressing neurons are involved in risk assessment behavior,22 and intracerebroventricular injection of UCN3 activates the stress-related hypothalamic-pituitary-adrenal (HPA) axis in rats.25 In addition, UCN3 is linked to sensations such as mechanosensitivity of the gastric vagal afferents36 and protection against age- and noise-induced hearing loss.14 Moreover, spinal Ucn3-Cre neurons have been found to have a role in mechanical itch and alloknesis.45 This evidence concerns the gene UCN3 and hearing loss disorder.