INS and gestational diabetes: Insulin content was increased in EndoC-βH3 cells treated with normal pregnancy psEVs (0.66 pmol/L, IQR: 0.46–0.75) and GDM psEVs (0.63 pmol/L, IQR: 0.52–0.73) relative to the sEV carrier controls (0.36 pmol/L, IQR: 0.26–0.44, p = 0.0423 for normal pregnancy psEVs and p = 0.0256 for GDM psEVs) and RBCsEVs (0.34 pmol/L, IQR: 0.26–0.43, p = 0.0423 for normal pregnancy psEVs and p = 0.0256 for GDM psEVs); however, no difference was noted between normal pregnancy and GDM psEVs (p > 0.99) (Figure 4D).