INS and gestational diabetes: The time course showed INS transcription increased at 30 hours when compared to the controls in both normal pregnancy (fold change = 2.48 in normal pregnancy psEVs vs. fold change = 0.62 in sEV carrier, p = 0.0364 and fold change = 0.72 in RBCsEVs, p = 0.0441) and GDM (fold change = 2.42 in GDM psEVs vs. fold change in sEV carrier, p = 0.0301 and in RBCsEVs, p = 0.0366, respectively) psEV treatments.