However, ANXA1 abundance was once more increased in EndoC-βH3 cells treated with normal pregnancy (log2 FC = 3.6, −log p-value = 4.3) and GDM psEVs (log2 FC = 3.82, −log p-value = 5.6) when compared to cells treated with the controls (sEV carrier control and RBCsEVs). Here, ANXA1 is linked to gestational diabetes.