Higher Apo-B levels indicate increased atherogenic particles, elevating the risk of atherosclerosis and CVDs.[70,79] Moreover, the Apo-B/Apo-A1 ratio has been extensively explored as a potential cardiovascular risk predictor.[83] Therefore, our meta-analyses reveal the potential implications of PS supplementation on lipid profiles and apolipoproteins and provide promising insights for early CVDs prevention. This evidence concerns the gene APOB and atherosclerosis.