CD4 and gout: Various T lymphocytes are involved in gout, with Th17, Th1, Th9, Th22, and γδ T cells promoting gout attacks, while Tregs and Th2 cells exert inhibitory effects.[21] Currently, research on T lymphocytes mainly focuses on the balance between Th1/Th2 and Th17/Treg cells within CD4 + T cell subtypes.