Studies have found that CD25 B cells are capable of effective antigen presentation and exhibit a more mature phenotype.[30] Recent research has discovered that an imbalance between CD25hi Bregs and CD4 Tregs is involved in the pathogenesis of Type 1 diabetes.[31] Unfortunately, there is currently a lack of research on the relationship between gout and CD25 on IgD CD24 B cells, with no definitive findings, necessitating further investigation to confirm. Here, CD4 is linked to gout.