DNT cells can secrete IL-17 and interferon-γ, participating in the pathogenesis of renal damage in patients with systemic lupus erythematosus (SLE).[27] Because DNT cells can migrate from peripheral blood to organs, infiltrating salivary glands, skin, and kidneys, they play a central role in the pathogenesis of Sjögren’s syndrome and psoriasis.[28,29] Furthermore, our study found that DNT cells are a risk factor for gout, providing clues and potential mechanisms for our research findings based on observational studies. This evidence concerns the gene IL17A and Sjogren syndrome.