As a result, the top 10 genes, namely VEGFR2, eNOS, AKT, MAPK1, PRKCA, IKBKB, IL6, MAPK3, RAF1, and vascular endothelial growth factor A (VEGFA), displayed high degree values and were predicted to be the potential targets for GXST treating HF for further investigation. The gene discussed is IKBKB; the disease is hydrops fetalis.