ABCC2 and acute liver failure: ABCB11 is a gene that encodes the bile salt export pump (BSEP) protein that is responsible for transporting bile salts from liver cells into the bile ducts for excretion.[33] Multidrug resistance protein 2 (MRP2) is a multidrug resistance protein that is involved in the excretion of bilirubin, and its loss can lead to hyperbilirubinemia and acute liver failure.[34] The relationship between ABCB11 (BSEP) and MRP2 is also reflected in the fact that they both contribute to the transport of bile salts from liver cells into the bile ducts.