In general, we observed that the critical research issues and public interest changed in 2 major aspects: from the mechanism(s) underlying ICP effects (such as the salt export pump, genetic basis, ABCB4/11, and p-glycoprotein) to the clinical aspects (such as stillbirth, preterm birth, and adverse pregnancy) (Fig. 7A). Here, ABCB1 is linked to Stillbirth.