Tumor tissue comprises tumor cells and other cells in the tumor microenvironment, such as fibroblasts, vascular endothelial cells, stromal cells, and immune cells.[47,48] Among them, immune cell infiltration can markedly influence breast cancer patient’s therapeutic response and outcome.[49,50] TIMER analysis found that cuproptosis-related genes were generally positively related to immunocyte infiltration, except for LIAS, with FDX1, DLAT, and GLS being more prominent. This evidence concerns the gene FDX1 and neoplasm.