As cuproptosis-promoting genes, FDX1, LIAS, LIPT1, DLD, DLAT, and PDHA1 were under-expressed in breast cancer; at the same time, CDKN2A, which inhibited cuproptosis, was over-expressed in breast cancer, suggesting that cuproptosis might involve in the protective mechanism of BRCA. This evidence concerns the gene LIAS and breast cancer.