As shown in Figure 1, cuproptosis core gene FDX1 was down-regulated in BRCA, cholangiocarcinoma, colorectal adenocarcinoma, kidney chromophobe carcinoma, kidney renal clear cell carcinoma, kidney renal papillary cell carcinoma, lung adenocarcinoma, lung squamous cell carcinoma, rectal adenocarcinoma, thyroid carcinoma but up-regulated in stomach adenocarcinoma. This evidence concerns the gene FDX1 and colorectal adenocarcinoma.