Morvan’s syndrome (MoS) is a rare cluster of neurological symptoms that includes a group from clinical syndromes marked by hyperexcitability of peripheral nerves, autonomous dysfunction, and encephalopathy, often with severe insomnia, ranging from mild to malignant forms characterized by total sleep loss, accompanied by dream enactment and apnea excitation associated with autoantibodies to voltage-gated and potassium channel (VGKC) complexes such as anti-contactin-associated protein-like 2 (Caspr2) antibody. The gene discussed is CNTNAP2; the disease is Encephalopathy.