In our study, elevated α-MSH levels in the HG group impacted feeding behavior and the food-related reward system.[16] Another peptide, CART, is proposed to have multiple functions, including regulating feeding, appetite suppression, addiction, stress, anxiety, innate fear, neurological diseases, neuropathic pain, depression, osteoporosis, insulin secretion, thirst, body temperature, learning, memory, reproduction, vision, and sleep regulation. Here, INS is linked to major depressive disorder.