These factors included higher HCC-nonB ratios, female gender, diabetes, smaller or fewer tumors, nodular hepatocellular carcinoma, lower metastasis rates, and levels closer to normal for various biochemical markers such as aspartate transaminase, alanine aminotransferase transaminase, albumin, total bilirubin (TB), direct bilirubin, alkaline phosphatase, glutamyl transpeptidase (GTT), lactate dehydrogenase, blood urea nitrogen, prothrombin time, activated partial thromboplastin time, international normalized ratio, D-dimer, procalcitonin, and C-reactive protein. Here, F2 is linked to hepatocellular carcinoma.