For mealtime insulin (Novorapid/ Humalog/ Fiasp): 50% of TDD/3 plus a safety adjustment (e.g. minus 30%) to minimise risk of hypoglycaemia.Titrate doses according to responseIf the person is able to carbohydrate count, prescribe a variable rapid‐acting insulin dose for self‐adjustment. The gene discussed is INS; the disease is Hypoglycemia.