IFNG and Sepsis: Other primary capsules were also involved in pathways related to the inflammation in sepsis, such as primary capsule 1 for T-cell activation (Fig 4C), primary capsule 3 for neuron death and interferon-gamma [20] (Fig 4E), primary capsule 4 for apoptotic signaling pathway (Fig 4F), primary capsule 6 for leukocyte cell-cell adhesion [21] (Fig 4H), and primary capsule 7 for reactive oxygen species metabolic process [22] (Fig 4I).