MLF1 and early-onset generalized limb-onset dystonia: In human cells, Mlf1 was specifically reported to influence the stability of p27Kip1 [3] and p53 by inhibiting their degradation by the proteasome [4], it participates in the regulation of ciliogenesis [5], and patients with mutated Hsp40 (DNAJB6) were found to accumulate Mlf1 in clusters with Hsp40 [6] In DYT1 dystonia, nonfunctional Torsin ATPase causes defects in the nuclear pore assembly, and the Mlf1 paralog Mlf2 relocalizes along with Hsp40/Hsp70 proteins to the nuclear envelope blebs [7,8].