FFAR2 and colorectal carcinoma: To note, when comparing changes in FFAR2 gene expression between CRC cells and non-CRC, an 11-fold and 9-fold increase after 4-CMTB and GSK137647 treatment, respectively, was observed in SW-480 vs. CCD 841 CoN cells (p = 0.0001) (Fig. 1c, S1c).