Lung disease, as defined by inflammation in lung washes, emphysema, and lung consolidation, was present in SHIP-1−/− mice regardless of ileitis phenotype; however, there was a shift in the nature of lung inflammation in animals with ileitis, with increased G-CSF and neutrophils, in addition to type 2 cytokines and eosinophils. The gene discussed is INPP5D; the disease is pulmonary emphysema.