To determine if gut disease in SHIP-1−/− mice influenced the bacterial microbiome, 16 S ribosomal RNA sequencing was used to characterise and compare the microbial composition of faecal samples from 12-week-old SHIP-1−/− mice with and without ileitis using matched SHIP-1+/− as controls. This evidence concerns the gene INPP5D and Crohn ileitis.