We have similarly found that G-CSF−/− mice are more susceptible to DSS-induced colitis (unpublished) and speculate that differing mechanisms and location of disease between DSS colitis and Crohn’s-like ileitis in SHIP-1−/− mice may account for the contrasting effects of G-CSF-deficiency on gut inflammation. The gene discussed is CSF3; the disease is hyperinsulinemic hypoglycemia, familial, 4.