While granulocyte infiltration, which included CD45+CD11b+Ly6G+ neutrophils and CD45+CD11b+Siglec-F+ eosinophils, was a feature of SHIP-1−/− mice with ileitis, this was not observed in the IEL or LP of SHIP-1−/− mice without ileitis (Fig. 2A and B). Here, INPP5D is linked to Crohn ileitis.