Consolidation of the lung tissue, characterised by an increase in immune cells both in the lung tissue and airspaces, is apparent in SHIP-1−/− mice, and whilst this consolidation appears more densely packed in SHIP-1−/− mice with ileitis, no significant difference was noted when consolidation was quantified as a percentage of positive tissue compared to airspaces in the whole lung (Fig. 4B and D). Here, INPP5D is linked to Crohn ileitis.