INPP5D and Crohn ileitis: However, there was a mild but non-significant increase in γδ T cells in the LP of SHIP-1−/− mice without ileitis compared to both SHIP-1−/− mice with ileitis and SHIP-1+/− controls, suggesting that γδ T cells may expand prior to ileitis onset potentially to regulate intestinal immune responses that could lead to ileitis (Fig. 2G).