Two further studies described a dual effect of extracellular vesicles (EVs) on the CD24-Siglec-10 axis: on the one hand, EVs derived from malignant ascites upregulate Siglec-10 expression in T cells, and on the other hand, cancer-associated adipocyte (CAA) EVs deliver SIRT1 to ovarian cancer cells and increase CD24 expression, both of which lead to activation of the abovementioned immune axis and thereby promote CD8+ T cell apoptosis [115, 116]. Here, CD24 is linked to ovarian cancer.