Similar to the protein level, the administration of a high dose of GUANKE reduced the transcription of CCL2 (the gene encoding MCP-1), TNFA, and IL6 on the third day after infection, and decreased the transcription of CCL2, TNFA, IL1B, IL6, and IL17C on the fifth day after infection (Fig. 3). The gene discussed is IL1B; the disease is infection.