ERCC1 and cancer: There is also evidence that certain SNPs within the ERCC1 gene can lead to decreased levels of ERCC1 mRNA and protein, which potentially impair cellular repair ability and ultimately promote cancer development.23-26 Moreover, several studies have confirmed a relationship between ERCC1 gene polymorphisms and NSCLC treatment efficacy.10,11,15,27,28 The results of a studyin Chinese patients revealed that individuals with the rs11615 TT genotype and the T allele or the rs3212986 AA genotype and the A allele had significantly lower response rates to treatment.