GNRH1 and Global developmental delay: Recently, loss‐of‐function variants in NLGN3 have been identified in patients with delayed puberty with partial hypogonadotropic hypogonadism in conjunction with ASD and/or developmental delay.[150] In a cellular model, loss of NLGN3 was demonstrated to impair GnRH neuronal neuritogenesis, suggesting that this synaptic protein may be important for neuronal network formation required for both GnRH biology and cognitive and social development.