NOS1 and cartilage-hair hypoplasia: Initiation of hormone therapy or other therapeutic interventions during minipuberty may lead to improved long‐term reproductive, behavioral, and cognitive impact, as suggested by the aforementioned animal studies administering NO to Nos1‐deficient mice.[48] It is established that boys with severe forms of CHH, who demonstrate phenotypic features such as cryptorchidism in infancy, have diminished responses to GnRH or combined gonadotropin replacement in adolescence or adult life.