GNRH1 and hypogonadotropic hypogonadism: In contrast, patients with delayed puberty due to hypogonadotropic hypogonadism (secondary to GnRH or gonadotropin deficiency) are reported to be at a higher risk of developing ASD and ADHD (Figure 2),[149] demonstrating that the link between ASD and pubertal timing is not unidirectional and that neuroendocrine and behavioral neuronal circuits may be influenced by a common mechanism.