The neuropathological picture shows cortical atrophy, neurofibrillary tangles (NFT) degeneration associated with hyperphosphorylated tau protein (p-tau) that aggregates intracellularly, and extracellular senile plaques resulting from the deposition of insoluble forms of Aβ peptide in the brain [54],[57]. Here, MAPT is linked to Cerebral cortical atrophy.