[9]. The complexity of MMP activity regulation encompasses transcriptional oversight, activation of dormant proenzymes, and inhibition through tissue inhibitors of metalloproteases (TIMPs) [10]. Dysregulation of MMP expression and activity is a hallmark of cancer progression and metastasis. Elevated levels of MMP-2 and MMP-9 potential corelated in increased invasive and metastatic potential in various cancers, including lung cancer [11]. The gene discussed is MMP9; the disease is cancer.