[43]. Similarly, previous reported by Zhao et al., 2018, indicate the resveratrol inhibit the cell migration, invasion and colony formation through modulation of MMPs, Akt and ERK1/2 in renal cell carcinoma cells [44]. Chen et al., 2021, demonstrate the Nicardipine potentially modulate MMP-9 to supress the Breast Cancer Migration [45]. This evidence concerns the gene MAPK3 and breast carcinoma.