We were interested in (1) models with alterations in any of the 102 high-confidence genes identified via large-scale exome sequencing by Satterstrom et al. (2020) and (2) models of Fragile X syndrome (FXS), Rett syndrome (RTT), and Angelman syndrome which have alterations in the Fmr1, Mecp2, and Ube3a genes, respectively. This evidence concerns the gene UBE3A and Rett syndrome.