The advancement and evolution of CRC encompass a multitude of signaling pathways, which encompass Wnt, PI3K/Akt, Hedgehog, ErbB, RHOA, Notch, BMP, AMP-activated protein kinase (AMPK), Hippo, NF-κB, MAPK, and JNK. The gene discussed is EGFR; the disease is colorectal carcinoma.