For example, deletion of endogenous mevalonate or blockage of the protein isoprenylation or decreased PI3K/Akt pathway led to arrest G0/G1 phase of the cell cycle; however, there is no apoptotic effect reported at 24 h of DHEA treatment in HT29 CRC cell (Armaghany et al., 2012; Schulz et al., 1992; Jiang et al., 2005). This evidence concerns the gene AKT1 and colorectal carcinoma.