For instance, Lao et al. (2018) reported that SENP3 enhances lipopolysaccharide (LPS) induced TLR4 signal transduction via the deSUMOylation of MKK7, and myeloid-specific deletion of SENP3 can alleviate LPS-induced endotoxic shock and acute lung injury (Chen et al., 2020). The gene discussed is SENP3; the disease is injury.