IL26 and tuberculosis: Therefore, given the multifunctional effects of IL-26 on chronic disease progression and the knowledge gap of IL-26 in macrophage activations and functionality, this study aimed to explore the clinical relevance and implications of IL-26 in tuberculosis disease progressions, as well as to elucidate the effect of IL-26 on the activation and killing ability of human macrophage for the invading Mtb bacilli, along with uncovering the underlying molecular mechanisms involved.