Furthermore, IFI27 expression is upregulated in the blood of SARS-CoV-2 positive patients (Gupta et al., 2021; Huang et al., 2021; Shojaei et al., 2022), and IFI27 is upregulated in the respiratory tract of COVID-19 patients (Mick et al., 2020; Kulasinghe et al., 2022; Shojaei et al., 2022). Here, IFI27 is linked to COVID-19.