HAVCR2 and neoplasm: We also observed that OT-I cells infiltrating MC38-OVA tumours expressed higher levels of PD-1 and TIM3 than OT-I cells infiltrating MC38-WT tumours in the same mouse as identified by expression of PD-1 and TIM3 (Figure S5F-H), consistent with antigen-specific activation within the OVA-expressing tumours.