STAT3 and cancer: REVs were found to enhance the expression of CAFs related proteins like αSMA, CD95, EMT marker vimentin, SLC1A5, and STAT3 phosphorylation as well as FAP expression after 48 hours exposure to REVs and SEVs (Figure 6F-G) suggesting that REVs can subvert stromal fibroblasts to adopt a cancer-promoting phenotype.