Brain pericyte-derived endothelial cells, fibroblasts and microglia following ischemic stroke have all been confirmed with genetic fate mapping using either Tbx18-CreERT2/Rosa26-tdTomato, Glast-CreERT2/Rosa26-tdTomato, or Rgs5-YFP mouse lines 11,14,15. The gene discussed is TBX18; the disease is ischemic stroke.