The transwell assay indicated that glioblastoma cells co-cultured with M2 (CD11b+/CD163+)-derived conditional medium in which EVs were excluded or inhibited by GW4689 showed decreased migration and invasion ability, and the decrease could be restrained by M2 (CD11b+/CD163+) derived EVs (Figures S1A-D). Here, CD163 is linked to glioblastoma.