According to reports, CXCR4 is highly expressed in B cells 34,35, while DLBCL is a highly malignant tumor originating from B lymphocytes, which may be the reason for the highest uptake of [18F]AlF-NOTA-QHY-04 in DLBCL patients. This evidence concerns the gene CXCR4 and diffuse large B-cell lymphoma.