Based on our previous work that [18F]AlF-NOTA-QHY-04 shows no acute radiotoxicity 20, so as to confirm the in vivo specificity and imaging efficacy, 60-min dynamic PET was firstly performed on mice bearing NCI-H69 subcutaneous tumor xenografts, which showed high CXCR4 expression in the tested wild-type cells (see below). The gene discussed is CXCR4; the disease is neoplasm.