G6PC1 and liver cancer: In the culture of murine liver cancer cells (H4IIE), it was found that 20-hydroxy ecdysone (20E) reduced the expression of phosphoenolpyruvate kinase (PEPCK) and glucose 6 phosphatase (G6Pase), decreased the content of glucose, and induced the sensitivity of Akt2 phosphorylation to phosphoserine 3 kinase-specific inhibitor LY-294002, which could reduce blood glucose and blood lipids.