Overexpression of miR-181c in human pancreatic cancer cells led to excessive activation of YAP/TAZ, along with increased expression of hippo signaling downstream genes CTGF, BIRC5, and BLC2L1, which improved the in vitro and in vivo survival and resistance of pancreatic cancer cells to chemotherapy (165). This evidence concerns the gene WWTR1 and pancreatic neoplasm.