The mRNA expression levels of potential mRNA vaccine targets were validated across various cohorts: (1) ITGB2: Expression levels were assessed in the Berthier Lupus Glomeruli, Berthier Lupus Tubulointerstitium, Peterson Lupus Glomeruli, and ERCB Lupus Tubulointerstitium cohorts (Figure 5A). The gene discussed is ITGB2; the disease is systemic lupus erythematosus.