Wherein NETs induced by G-CSF manifest diversified biomedical behaviors such as capture of circulating tumor cells, epithelial-to-mesenchymal transition, and increment of vascular permeability, which promote cancer-associated thrombosis, tumor intravasation, and metastasis, as well as laminin remodeling and immunosuppressive behaviors, which conduce to tumor proliferation and metastasis (35). The gene discussed is CSF3; the disease is neoplasm.