The DNA ingredients of NETs (NET-DNA) in the liver are chemotactic for tumor cells through interplay with high affinity with the coiled-coil domain containing protein 25 (CCDC25) that is a transmembrane protein expressed on tumor cells so that DNA-CCDC25 interplay triggers an intracellular signaling cascade facilitating tumor cell directional migration and metastasis formation (37). The gene discussed is CCDC25; the disease is neoplasm.