Another specific subpopulation of TANs discerned in sarcoma and expressing augmented CD11b and CD54, along with diminished CD62L, has been shown an exceptional cytokine secretion profile, encompassing C-X-C Motif Chemokine Ligand (CXCL)10, interleukin (IL)-23a, and arginase-1, which in conjunction with IL-12 secreted by macrophages synergistically robustly boost the CD4−CD8− unconventional αβ T cell polarization and their IFN-γ secretion, thereby triggering a type I immune response against tumor (49). The gene discussed is ITGAM; the disease is sarcoma.