And the endpoint of Lineage 2 was a subtype of C1 SRSF7+ MCs, this result may prove that MCs are affected by some cytokines or tumor cell-secreted proteins during their development in the TME, leading to the transformation of MCs into a tumor-associated or pro-tumor phenotype, which is in line with the previous study (69). The gene discussed is SRSF7; the disease is neoplasm.