EGF and neoplasm: EGF was present in the incoming pathway of tumor-cells, i.e., tumor-cells were the target cells, and EGF is again present in the outgoing pathway of C1 SRSF7+ MCs subtype, i.e. C1 SRSF7+ MCs subtype was the secreting cell, which links C1 SRSF7+ MCs subtype and tumor-cells, we speculated that this signaling pathway might be related to tumor progression, so we next focused on EGF.