APP and neoplasm: For instance, this output indicated that the majority of outgoing MCs signaling was characterized by pattern 1, which represented multiple pathways, including but not limited to CD99, ANNFXIN, EGF, PARs, ICAM, CSF, etc. All output tumor-cells, fibroblasts, ECs, SMCs, neurons signalings were characterized by pattern 2, which represented pathways such as COLLAGEN, LAMININ, FN1, APP, PTN and so on.