ALCAM and neoplasm: The C1 SRSF7+ MCs subtype belongs to mode 1 in the outgoing pathway, and its communication molecules, i.e., ligands, include ANNEXIN, PARs, CSF, ICAM, etc.; and it belongs to mode 2 in the incoming pathway, and its communication molecules, i.e., receptors, include BAFF, CLEC, ALCAM, SELPG, etc. It is also worth noting that tumor cells, which can be learned after our careful observation, belong to mode 2 on the outgoing and mode 1 on the incoming, echoing the subtype of C1 SRSF7+ MCs, which drew our attention.