HMGB1 and neoplasm: Various forms of ICD are observed following OV infection, which enhances tumor cell oncolysis (164), then a large number of damage-associated molecular patterns (DAMPs) including calreticulin, heat-shock proteins (HSPs), ATP, uric acid, high mobility group box 1 (HMGB1), pathogen-associated molecular patterns (PAMPs) including viral elements, tumor-associated antigens (TAAs) and cytokines (including IL-2, TNF-α, IFN-γ) are released (104, 165, 166).