Notable examples include circNEIL3, which recruits the E3 ubiquitin ligase Nedd4L to degrade YBX1, inhibiting tumor metastasis (30); circCDYL2, which enhances colorectal cancer (CRC) migration by binding to Ezrin and promoting AKT phosphorylation through its upregulation (31); and circARID1A, which binds to IGF2BP3 protein, forming a ternary complex with SLC7A5 that boosts gastric cancer proliferation via the AKT/mTOR pathway (32). The gene discussed is AKT1; the disease is colorectal carcinoma.