We previously reported total activity drops for the Miller Syndrome related DHODH variants c.56G > A, p.(G19E), c.155A > G, p.(E52G) and c.403C > T, p.(R135C) to activity levels corresponding to 24 %, 20 % and 15 % of the wild-type DHODH activity, respectively [16]. This evidence concerns the gene DHODH and postaxial acrofacial dysostosis.