The high HSPscore tumors were characterized by the increased expression of CCT7, DNAJC10, HSPB8, HSPE1, HSPD1, HSPA4L, HSP90B1, DNAJC1, and CCT3; and osteosarcoma patients with depressed HSPscores exhibited significant increases in the expression of DNAJC8, HSPA1L, DNAJB5, DNAJC17, DNAJC5B, and DNAJC5 (Figure 2K). The gene discussed is HSPA4L; the disease is osteosarcoma.