Extensive research currently delves into the potential role of individual HSPs such as HSPB1, HSPBP1, and HSP90AA1 in influencing the survival and advancement of osteosarcoma, yet the prognostic value and molecular mechanisms of other HSP family members in osteosarcoma remain to be elucidated 72-77. Here, HSPB1 is linked to osteosarcoma.