The group with low HSPscore had a remarkable presence of both innate and adaptive immune cells, including CD8(+) T cells, dendritic cells (DCs), macrophages, mast cells, neutrophils, plasmacytoid dendritic cells (pDCs), tumor-infiltrating lymphocytes (TILs), natural killer (NK) cells, T helper cells, T follicular helper (Tfh) cells, Th2 cells, and regulatory T cells (Tregs) (Figure 3M, Figure S3). This evidence concerns the gene CD8A and neoplasm.